Thursday, December 31, 2009

Writing in the journal Radiologic Clinics

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The association between gadolinium (Gd)-containing MR imaging contrast agents and the development of nephrogenic systemic fibrosis (INISF) is well recognized. The authors review the histopathologic features, methodology, and results Of analysis of tissues for Gd in NSF," scientists writing in the journal Radiologic Clinics of North America report (see also Fibrosis).

"Scanning electron microscopy/energy dispersive xray spectroscopy (SEM/EDS) provides sensitive detection of individual Gd-containing deposits in situ. Secondary ion mass spectroscopy has far greater sensitivity for detection of Gd than SEM/EDS and allows correlation at the cellular level. Inductively coupled plasma mass spectrometry is the recognized method for full quantitative analysis of Gd in tissues but requires destruction of the tissue and does not allow spatial correlation," wrote C. Thakral and colleagues.

The researchers concluded: "In practice, the different analytic techniques provide complementary data and can be selected based on the information required."

Thakral and colleagues published their study in Radiologic Clinics of North America (Nephrogenic Systemic Fibrosis: Histology and Gadolinium Detection. Radiologic Clinics of North America, 2009;47(5):841+).

Additional information can be obtained by contacting J.L. Abraham, Upstate Med University, State University New York, Dept. of Pathology, Syracuse, NY 13210, USA.

The publisher of the journal Radiologic Clinics of North America can be contacted at: W B Saunders Co-Elsevier Inc., 1600 John F Kennedy Boulevard, Ste. 1800, Philadelphia, PA 19103-2899, USA.

Keywords: United States, Syracuse, Electron Microscopy, Fibrosis, Hepatology, Histology, Histopathology, Mass Spectrometry, Spectroscopy, Surgery.

This article was prepared by Biotech Week editors from staff and other reports. Copyright 2009, Biotech Week via

Source Citation
"Data from C. Thakral and colleagues advance knowledge in fibrosis." Biotech Week 18 Nov. 2009: 994. Academic OneFile. Web. 31 Dec. 2009. .

Gale Document Number:A211856723

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